Title: Solid-phase synthesis of the 2(1H)-pyrazinone scaffold: A new approach toward diversely substituted heterocycles
Authors: Kaval, N ×
Dehaen, Wim
Van der Eycken, Erik #
Issue Date: Jan-2005
Publisher: Amer chemical soc
Series Title: Journal of combinatorial chemistry vol:7 issue:1 pages:90-95
Abstract: The first solid-phase synthesis of the 2(1H)-pyrazinone scaffold is described. The diversity at position C6 of the pyrazinone ring is determined by the choice of the starting aldehyde. Microwave-enhanced transition metal-catalyzed reactions allow easy introduction of a variety of substituents at the C3 position. This opens a way for the generation of libraries of diversely substituted 2(1H)-pyrazinones that will be screened for biological activities.
ISSN: 1520-4766
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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