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Title: A spatiotemporal statistical atlas of motion for the quantification of abnormal myocardial tissue velocities
Authors: Duchateau, Nicolas ×
De Craene, Mathieu
Piella, Gemma
Silva, Etelvino
Doltra, Adelina
Sitges, Marta
Bijnens, Bart
Frangi, Alejandro F #
Issue Date: Jun-2011
Publisher: Oxford University Press
Series Title: Medical Image Analysis vol:15 issue:3 pages:316-328
Abstract: In this paper, we present a new method for the automatic comparison of myocardial motion patterns and the characterization of their degree of abnormality, based on a statistical atlas of motion built from a reference healthy population. Our main contribution is the computation of atlas-based indexes that quantify the abnormality in the motion of a given subject against a reference population, at every location in time and space. The critical computational cost inherent to the construction of an atlas is highly reduced by the definition of myocardial velocities under a small displacements hypothesis. The indexes we propose are of notable interest for the assessment of anomalies in cardiac mobility and synchronicity when applied, for instance, to candidate selection for cardiac resynchronization therapy (CRT). We built an atlas of normality using 2D ultrasound cardiac sequences from 21 healthy volunteers, to which we compared 14 CRT candidates with left ventricular dyssynchrony (LVDYS). We illustrate the potential of our approach in characterizing septal flash, a specific motion pattern related to LVDYS and recently introduced as a very good predictor of response to CRT.
URI: 
ISSN: 1361-8415
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Cardiovascular Imaging and Dynamics
× corresponding author
# (joint) last author

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