Title: Identifiability of a model for diffusion-mediated intramolecular excited-state quenching
Authors: Novikov, Eugene ×
Molski, A
Boens, Noël #
Issue Date: Jan-2000
Publisher: Amer inst physics
Series Title: Journal of Chemical Physics vol:112 issue:12 pages:5348-5352
Abstract: A model for diffusion-mediated intramolecular fluorescence quenching based on the analytical solution of the Smoluchowski differential equation is considered. It is assumed that quenching occurs with a finite intrinsic rate at the distance of closest contact between the reactants. The solution has been worked out in terms of Laplace transforms with the aim to perform a deterministic identifiability study of this model. It is shown that the rate constant of excited-state deactivation and the system dimensionality can be uniquely recovered without additional information from a single fluorescence decay trace. The other system parameters (the diffusion coefficient, the intrinsic reaction rate constant, the distance of closest approach, and the distance of maximal separation), influencing the diffusion-controlled quenching, can be determined up to a scaling factor. However, if a priori information about one of these parameters is available, the model becomes globally identifiable (i.e., all model parameters can be uniquely determined). (C) 2000 American Institute of Physics. [S0021-9606(00)00211-7].
ISSN: 0021-9606
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
× corresponding author
# (joint) last author

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