Title: Kinetic plot based comparison of the efficiency and peak capacity of high-performance liquid chromatography columns: Theoretical background and selected examples
Authors: Broeckhoven, Ken ×
Cabooter, Deirdre
Eeltink, Sebastiaan
Desmet, Gert #
Issue Date: Aug-2011
Publisher: Elsevier
Series Title: Journal of Chromatography A vol:1228 pages:20-30
Abstract: The present contribution reviews the foundations of the kinetic-plot method for the direct comparison of the kinetic performance of different chromatographic support and operating modes. The method directly uses experimental data collected for a specific sample and operating condition of one's interest, and is applicable both under isocratic- and gradient-elution conditions. Experimental proof is provided for the strong relation between the kinetic performance of a given support under isocratic and gradient conditions: a material offering superior kinetic performances under isocratic conditions will remain superior under gradient conditions and vice versa provided the comparison occurs under unbiased conditions. In addition, a review is made of the recent literature using the kinetic-plot method to compare and assess the kinetic performance of high performance HPLC columns and their operation mode.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

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