Title: Ultra-rapid separation of an angiotensin mixture in nanochannels using shear-driven chromatography
Authors: Vankrunkelsven, Sarah
Clicq, David
Cabooter, Deirdre
De Malsche, Wim
Gardeniers, J G E
Desmet, Gert # ×
Issue Date: Jan-2006
Publisher: Elsevier
Series Title: Journal of Chromatography A vol:1102 issue:1-2 pages:96-103
Abstract: The present paper reports on the separation of a mixture of fluorescein isothiocyanate-labeled angiotensin I and II peptides in a shear-driven nanochannel with a C18-coating and using an eluent consisting of 5% acetonitrile in 0.02 M aqueous phosphate buffer at pH 6.5. The flat-rectangular nanochannel in fused silica consisted of an etched structure in combination with a flat moving wall. The very fast separation kinetics that can be achieved in a nanochannel allowed to separate the angiotensin peptides in less then 0.2 s in a distance of only 1.8 mm. Plate heights as small as 0.4 microm were calculated after substraction of the injection effect.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science