Title: Future of high pressure liquid chromatography: Do we need porosity or do we need pressure?
Authors: Desmet, Gert ×
Cabooter, Deirdre
Gzil, Piotr
Verelst, Harry
Mangelings, Debby
Vander Heyden, Yvan
Clicq, David #
Issue Date: Oct-2006
Publisher: Elsevier
Series Title: Journal of Chromatography A vol:1130 issue:1 pages:158-166
Conference: International Symposium on Hyphenated Techniques in Chromatography and Hyphenated Chromatographic Analyzers (HTS-9) edition:9 location:York: ENGLAND date:8-10 February 2006
Abstract: Making a theoretical study supported by experiments of the kinetic advantages of increased inlet pressures versus increased external porosity using impedance plots of analysis time versus required plate number, it is found that both approaches more or less have the same effect on the kinetic performance. The need to change a given system to one with an increased inlet pressure or with an increased external porosity can best be assessed from the optimal plate number (N-opt) of the system. When the pursued application requires a plate number that is larger than N-opt, any increase in inlet pressure and external porosity is beneficial. When the required plate number is smaller than N-opt, any increase in inlet pressure and external porosity should preferentially be accompanied by an overall reduction of the feature sizes of the support. The degree to which this feature size reduction can be realized in practice will to a large extent determine which of the two approaches will be the dominant system of the future. (c) 2006 Elsevier B.V. All rights reserved.
ISSN: 0021-9673
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Non-KU Leuven Association publications
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science