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Title: The synthesis of 5-substituted 6-oxo-2-piperidinecarboxylic acid derivatives from cyclopentanone-beta-ketoesters
Authors: Compernolle, Frans ×
Baens, N
Hoornaert, Georges #
Issue Date: Jan-1997
Publisher: Comite van beheer van het bulletin vzw
Series Title: Bulletin des societes chimiques belges vol:106 issue:7-8 pages:433-437
Abstract: Ethyl 2-oxocyclopentanonecarboxylate was converted to 5-substituted 6-oxopiperidinecarboxylic derivatives via a synthetic sequence consisting of a) C-1-alkylation of the cyclopentanone-beta-ketoester b) introduction of a protected amino group at the alpha'-position (C-3) of the cyclopentanone carbonyl group via bromination and substitution with phthalimide c) base promoted ring opening of the disubstuted cyclopentanone-beta-ketoester to form the corresponding diester or ester-acid derivatives and d) final deprotection of the amino group with concomitant ring closure to produce the title compounds.
ISSN: 0037-9646
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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