Title: Cerebrovascular disorders: molecular insights and therapeutic opportunities
Authors: Storkebaum, Erik ×
Quaegebeur, Annelies
Vikkula, Miikka
Carmeliet, Peter #
Issue Date: 2011
Publisher: Nature America Inc.
Series Title: Nature Neuroscience vol:14 issue:11 pages:1390-1397
Article number: 10.1038/nn.2947
Abstract: Blood vessels in the nervous system have traditionally been considered neutral bystanders that only passively adapt their structure and function in response to the needs of neural cells. Emerging evidence suggests, however, that vessels and angiogenic molecules actively participate in the pathogenesis of neurological disorders. Here we will discuss molecular insights into neurological disorders resulting either from excessive vessel growth (cerebral vascular malformations) or improper vessel regression (neurodegeneration and white matter lesions). These genetic insights offer alternative therapeutic options, some of which are being evaluated in the clinic.
ISSN: 1097-6256
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Laboratory of Behavioral and Developmental Genetics
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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