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Title: Is PPARα intron 7 G/C polymorphism associated with muscle strength characteristics in nonathletic young men?
Authors: Broos, Siacia
Windelinckx, An
De Mars, Gunther
Huygens, Wim
Peeters, Maarten
Aerssens, Jeroen
Vlietinck, Robert
Beunen, Gaston
Thomis, Martine # ×
Issue Date: Aug-2013
Publisher: Munksgaard
Series Title: Scandinavian journal of medicine & science in sports vol:23 issue:4 pages:494-500
Abstract: Peroxisome proliferator-activated receptor alpha (PPARα), a ligand-dependent transcription factor, regulates fatty acid metabolism in heart and skeletal muscle. The intron 7 G/C polymorphism (rs4253778) has been associated with athletic performance. The rare C-allele was predominant in power athletes, whereas the G-allele was more frequent in endurance athletes. In the present study, we investigated the association between this polymorphism and strength characteristics in nonathletic, healthy young adults (n = 500; age 24.2 ± 4.4 years). Knee torque was measured during concentric knee flexion and extension movements at 60°/s, 120°/s, and 240°/s during 3, 25, and 5 repetitions, respectively. Also, resistance to muscle fatigue (i.e. work last 20% repetitions/work first 20% repetitions *100) was calculated. Differences in knee strength phenotypes between GG homozygous individuals and C-allele carriers were analyzed. The polymorphism did not influence the ability to produce isometric or dynamic knee flexor or extensor peak torque during static or dynamic conditions in this population (0.23 < P < 0.95). Similar results were found for the endurance ratio, a measure for resistance to muscle fatigue. In conclusion, the PPARα intron 7 G/C polymorphism does not seem to influence strength characteristics in a nonathletic population.
ISSN: 0905-7188
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Policy in Sports & Physical Activity Research Group
Exercise Physiology Research Group
Physical Activity, Sports & Health Research Group
× corresponding author
# (joint) last author

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