Title: Walking patterns in Parkinson's disease with and without freezing of gait
Authors: Nanhoe-Mahabier, W ×
Snijders, A H
Delval, A
Weerdesteyn, V
Duysens, Jaak
Overeem, S
Bloem, B R #
Issue Date: May-2011
Publisher: Pergamon Press
Series Title: Neuroscience vol:182 pages:217-24
Abstract: The pathophysiology underlying freezing of gait (FOG) in Parkinson's disease remains incompletely understood. Patients with FOG ("freezers") have a higher temporal variability and asymmetry of strides compared to patients without FOG ("non-freezers"). We aimed to extend this view, by assessing spatial variability and asymmetry of steps and interlimb coordination between the upper and lower limbs during gait. Twelve freezers, 15 non-freezers, and 15 age-matched controls were instructed to walk overground and on a treadmill. Kinematic data were recorded with a motion analysis system. Both freezers and non-freezers showed an increased spatial variability of leg movements compared to controls. In addition, both patient groups had a deficit in interlimb coordination, not only between ipsilateral arms and legs, but also between diagonally positioned limbs. The only difference between freezers and non-freezers was a decreased step length during treadmill walking. We conclude that parkinsonian gait-regardless of FOG-is irregular, not only in the legs, but also with respect to interlimb coordination between the arms and legs. FOG is reflected by abnormal treadmill walking, presumably because this provides a greater challenge to the defective supraspinal control than overground walking, hampering the ability of freezers to increase their stride length when necessary.
ISSN: 0306-4522
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Movement Control & Neuroplasticity Research Group
× corresponding author
# (joint) last author

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