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Title: A versatile stereospecific synthesis of the 1,3-disubstituted benzo [a]quinolizidine framework via 2-aryl substituted pyridines
Authors: Van der Eycken, Erik ×
Deroover, G
Toppet, SM
Hoornaert, GJ #
Issue Date: Jan-1999
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:40 issue:51 pages:9147-9150
Abstract: The stereospecific synthesis of the 1,3-disubstituted benzo[a]quinolizidine 6 is described starting from the easily accessible 3-arylated-6-substituted oxazinone 2. The skeleton is elaborated via an intramolecular aromatic substitution on the alpha-amino aldehyde obtained by treatment of the intermediate piperidine 4 with glycidol and consecutive oxidative cleavage of the diol. (C) 1999 Elsevier Science Ltd. All rights reserved.
URI: 
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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