Title: Refinement of 1p36 Alterations Not Involving PRDM16 in Myeloid and Lymphoid Malignancies
Authors: Duhoux, Francois P ×
Ameye, Geneviève
Lambot, Virginie
Herens, Christian
Lambert, Frédéric
Raynaud, Sophie
Wlodarska, Iwona
Michaux, Lucienne
Roche-Lestienne, Catherine
Labis, Elise
Taviaux, Sylvie
Chapiro, Elise
Khac, Florence Nguyen
Struski, Stéphanie
Dobbelstein, Sophie
Dastugue, Nicole
Lippert, Eric
Speleman, Frank
Van Roy, Nadine
De Weer, An
Rack, Katrina
Talmant, Pascaline
Richebourg, Steven
Mugneret, Francine
Tigaud, Isabelle
Mozziconacci, Marie-Joëlle
Laibe, Sophy
Nadal, Nathalie
Terré, Christine
Libouton, Jeanne-Marie
Decottignies, Anabelle
Vikkula, Miikka
Poirel, Hélène A
on behalf of the Groupe Francophone de Cytogénétique Hématologique (GFCH) and of the Belgian Cytogenetic Group for Hematology and Oncology (BCG-HO) #
Issue Date: 2011
Publisher: Public Library of Sciene
Series Title: PLoS One vol:6 issue:10 pages:e26311
Article number: 10.1371/journal.pone.0026311
Abstract: Fluorescence in situ hybridization was performed to characterize 81 cases of myeloid and lymphoid malignancies with cytogenetic 1p36 alterations not affecting the PRDM16 locus. In total, three subgroups were identified: balanced translocations (N = 27) and telomeric rearrangements (N = 15), both mainly observed in myeloid disorders; and unbalanced non-telomeric rearrangements (N = 39), mainly observed in lymphoid proliferations and frequently associated with a highly complex karyotype. The 1p36 rearrangement was isolated in 12 cases, mainly myeloid disorders. The breakpoints on 1p36 were more widely distributed than previously reported, but with identifiable rare breakpoint cluster regions, such as the TP73 locus. We also found novel partner loci on 1p36 for the known multi-partner genes HMGA2 and RUNX1. We precised the common terminal 1p36 deletion, which has been suggested to have an adverse prognosis, in B-cell lymphomas [follicular lymphomas and diffuse large B-cell lymphomas with t(14;18)(q32;q21) as well as follicular lymphomas without t(14;18)]. Intrachromosomal telomeric repetitive sequences were detected in at least half the cases of telomeric rearrangements. It is unclear how the latter rearrangements occurred and whether they represent oncogenic events or result from chromosomal instability during oncogenesis.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

Files in This Item:
File Description Status SizeFormat
Duhoux.pdfpublisher's version pdf Published 906KbAdobe PDFView/Open Request a copy

These files are only available to some KU Leuven Association staff members


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science