Title: Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-naphthyridine scaffold
Authors: Rombouts, FJR ×
Van den Bossche, J
Toppet, SM
Compernolle, Frans
Hoornaert, GJ #
Issue Date: Jan-2003
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron vol:59 issue:26 pages:4721-4731
Abstract: Two analogues of formerly described piperidine-based Substance P antagonists have been synthesised using an intramolecular Diels-Alder reaction of 1-(4-pentenyl)-3-phenyl-2(1H)-pyrazinones, followed by acidic methanolysis of the strained adducts to form the 8-oxo-6-phenyldecahydro [1,7]-naphthyridine-6-carboxylate esters and further conversion to the corresponding O-benzyl substituted 6-(hydroxymethyl) target compounds. Conformational analyses of intermediates and the final products are presented, based on H-1 NMR and modelling data. (C) 2003 Elsevier Science Ltd. All rights reserved.
ISSN: 0040-4020
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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