Title: Disturbed Cortico-Subcortical Interactions During Motor Task Switching in Traumatic Brain Injury
Authors: Leunissen, Inge ×
Coxon, James
Geurts, Monique
Caeyenberghs, Karen
Michiels, Karla
Sunaert, Stefan
Swinnen, Stephan #
Issue Date: Jun-2013
Publisher: Wiley-Liss
Series Title: Human Brain Mapping vol:34 issue:6 pages:1254-71
Abstract: The ability to suppress and flexibly adapt motor behavior is a fundamental mechanism of
cognitive control, which is impaired in traumatic brain injury (TBI). Here, we used a combination of
functional magnetic resonance imaging and diffusion weighted imaging tractography to study changes
in brain function and structure associated with motor switching performance in TBI. Twenty-three
young adults with moderate-severe TBI and twenty-six healthy controls made spatially and temporally
coupled bimanual circular movements. A visual cue signaled the right hand to switch or continue its
circling direction. The time to initiate the switch (switch response time) was longer and more variable
in the TBI group and TBI patients exhibited a higher incidence of complete contralateral (left hand)
movement disruptions. Both groups activated the basal ganglia and a previously described network
for task-set implementation, including the supplementary motor complex and bilateral inferior frontal
cortex (IFC). Relative to controls, patients had significantly increased activation in the presupplementary
motor area (preSMA) and left IFC, and showed underactivation of the subthalamic nucleus (STN)
region. This altered functional engagement was related to the white matter microstructural properties
of the tracts connecting preSMA, IFC, and STN. Both functional activity in preSMA, IFC, and STN,
and the integrity of the connections between them were associated with behavioral performance across
patients and controls. We suggest that damage to these key pathways within the motor switching network
because of TBI, shifts the patients toward the lower end of the existing structure-function-behavior
ISSN: 1065-9471
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Movement Control & Neuroplasticity Research Group
Translational MRI (+)
× corresponding author
# (joint) last author

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