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Title: Controlled release of chlorhexidine antiseptic from microporous amorphous silica applied in open porosity of an implant surface
Authors: Verraedt, E. ×
Braem, Annabel
Chaudhari, Amol
Thevissen, Karin
Adams, Erwin
Van Mellaert, Lieve
Cammue, Bruno
Duyck, Joke
Anné, Jozef
Vleugels, Jef
Martens, Johan #
Issue Date: Oct-2011
Publisher: Elsevier/North Holland
Series Title: International Journal of Pharmaceutics vol:419 issue:1-2 pages:28-32
Abstract: Amorphous microporous silica (AMS) serving as a reservoir for controlled release of a bioactive agent was applied in the open surface porosity of a titanium coating on a Ti-6Al-4V metal substrate. The pores of the AMS emptied by calcination were loaded with chlorhexidine diacetate (CHX) via incipient wetness impregnation with CHX solution, followed by solvent evaporation. Using this CHX loaded AMS system on titanium substrate sustained release of CHX into physiological medium was obtained over a 10 day-period. CHX released from the AMS coating was demonstrated to be effective in killing planktonic cultures of the human pathogens Candida albicans and Staphylococcus epidermidis. This surface modification of titanium bodies with AMS controlled release functionality for a bioactive compound potentially can be applied on dental and orthopaedic implants to abate implant-associated microbial infection.
ISSN: 0378-5173
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
Department of Materials Engineering - miscellaneous
Prosthetics
Pharmaceutical Analysis
Laboratory of Molecular Bacteriology (Rega Institute)
Physical Metallurgy and Materials Engineering Section (-)
Centre for Surface Chemistry and Catalysis
× corresponding author
# (joint) last author

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