Title: Micro-positron emission tomography imaging of rat brain metabolism during expression of contextual conditioning
Authors: Luyten, Laura
Casteels, Cindy
Vansteenwegen, Deb
van Kuyck, Kris
Koole, Michel
Van Laere, Koen
Nuttin, Bart # ×
Issue Date: 4-Jan-2012
Publisher: The Society for Neuroscience
Series Title: Journal of Neuroscience vol:32 issue:1 pages:254-263
Abstract: Using (18)F-fluorodeoxyglucose microPET imaging, we investigated the neurocircuitry of contextual anxiety versus control in awake, conditioned rats (n = 7-10 per group). In addition, we imaged a group expressing cued fear. Simultaneous measurements of startle amplitude and freezing time were used to assess conditioning. To the best of our knowledge, no neuroimaging studies in conditioned rats have been conducted thus far, although visualizing and quantifying the metabolism of the intact brain in behaving animals is clearly of interest. In addition, more insight into the neurocircuitry involved in contextual anxiety may stimulate the development of new treatments for anxiety disorders. Our main finding was hypermetabolism in a cluster comprising the bed nucleus of the stria terminalis (BST) in rats expressing contextual anxiety compared with controls. Analysis of a subset of rats showing the best behavioral results (n = 5 per subgroup) confirmed this finding. We also observed hypermetabolism in the same cluster in rats expressing contextual anxiety compared with rats expressing cued fear. Our results provide novel evidence for a role of the BST in the expression of contextual anxiety.
ISSN: 0270-6474
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre for Psychology of Learning and Experimental Psychopathology
Research Group Experimental Neurosurgery and Neuroanatomy
Nuclear Medicine & Molecular Imaging
× corresponding author
# (joint) last author

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