Title: IL28B polymorphism and the control of hepatitis C virus infection: ready for clinical use?
Authors: Orlent, Hans ×
Reynaert, Hendrik
Bourgeois, Stefan
Dideberg, V
Adler, Michael
Colle, I
Demaegt, S
Laleman, Wim
Michielsen, P
Moreno, C
Mulkay, JP
Stärkel, P
Delwaide, J #
Issue Date: Jun-2011
Publisher: Acta Medica Belgica
Series Title: Acta Gastro-Enterologica Belgica vol:74 issue:2 pages:317-322
Article number: 21861317
Abstract: Polymorphisms in the region of the interleukin-28B (IL28B) gene have recently been associated with spontaneous and treatment induced clearance of hepatitis C virus infection. The specific mechanisms of how IL28B polymorphisms affect HCV suppression remain unknown. It is a matter of ongoing debate how to incorporate the IL28B data into the current treatment algorithms with pegylated interferon-alpha and ribavirin. The eventual role of the IL28B genotype in new therapeutic regimes with direct antiviral agents needs to be explored in the ongoing and future clinical studies with these agents.
ISSN: 0001-5644
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
× corresponding author
# (joint) last author

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