Title: Vitamin D and diabetes: Its importance for beta cell and immune function
Authors: Wolden-Kirk, Heidi ×
Overbergh, Lut
Christesen, Henrik Thybo
Brusgaard, Klaus
Mathieu, Chantal #
Issue Date: Dec-2011
Publisher: Elsevier
Series Title: Molecular and Cellular Endocrinology vol:347 issue:1-2 pages:106-120
Abstract: Experimental evidence indicates that vitamin D may play a role in the defense against type 1 diabetes (T1D) as well as type 2 diabetes (T2D). Epidemiological data have established a link between vitamin D deficiency and an increased incidence of both T1D and T2D, whereas early and long-term vitamin D supplementation may decrease the risk of these disorders. The protective effects of vitamin D are mediated through the regulation of several components such as the immune system and calcium homeostasis. However, an increasing amount of evidence suggests that vitamin D also affects beta cells directly thereby rendering them more resistant to the types of cellular stress encountered during T1D and T2D. This review evaluates the role of vitamin D signaling in the pathogenesis of T1D and T2D with a special emphasis on the direct effects of vitamin D on pancreatic beta cells.
ISSN: 0303-7207
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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