Title: The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients
Authors: de Jonge, Hylke
Metalidis, Christoph
Naesens, Maarten
Lambrechts, Diether
Kuypers, Dirk # ×
Issue Date: Sep-2011
Publisher: Ashley Publications
Series Title: Pharmacogenomics vol:12 issue:9 pages:1281-1291
Abstract: Recently a SNP of the gene encoding P450 oxidoreductase (POR*28; rs1057868C>T) has been associated with increased in vivo CYP3A activity using midazolam as a drug probe. Because tacrolimus is metabolized by CYP3A isoenzymes, this SNP might affect tacrolimus pharmacokinetics.
ISSN: 1462-2416
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Laboratory of Nephrology
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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