Title: Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer
Authors: Stevens, Kristen N ×
Vachon, Celine M
Lee, Adam M
Slager, Susan
Lesnick, Timothy
Olswold, Curtis
Fasching, Peter A
Miron, Penelope
Eccles, Diana
Carpenter, Jane E
Godwin, Andrew K
Ambrosone, Christine
Winqvist, Robert
Brauch, Hiltrud
on behalf of the GENICA consortium
Schmidt, Marjanka K
Cox, Angela
Cross, Simon S
Sawyer, Elinor
Hartmann, Arndt
Beckmann, Matthias W
Schulz-Wendtland, Rüdiger
Ekici, Arif B
Tapper, William J
Gerty, Susan M
Durcan, Lorraine
Graham, Nikki
Hein, Rebecca
Nickels, Stephan
Flesch-Janys, Dieter
Heinz, Judith
Sinn, Hans-Peter
Konstantopoulou, Irene
Fostira, Florentia
Pectasides, Dimitrios
Dimopoulos, Athanasios M
Fountzilas, George
Clarke, Christine L
Balleine, Rosemary
Olson, Janet E
Fredericksen, Zachary
Diasio, Robert B
Pathak, Harsh
Ross, Eric
Weaver, Joellen
Rüdiger, Thomas
Försti, Asta
Dünnebier, Thomas
Ademuyiwa, Foluso
Kulkarni, Swati
Pylkäs, Katri
Jukkola-Vuorinen, Arja
Ko, Yon-Dschun
Van Limbergen, Erik
Janssen, Hilde
Peto, Julian
Fletcher, Olivia
Giles, Graham G
Baglietto, Laura
Verhoef, Senno
Tomlinson, Ian
Kosma, Veli-Matti
Beesley, Jonathan
Greco, Dario
Blomqvist, Carl
Irwanto, Astrid
Liu, Jianjun
Blows, Fiona M
Dawson, Sarah-Jane
Margolin, Sara
Mannermaa, Arto
Martin, Nicholas G
Montgomery, Grant W
Lambrechts, Diether
Dos Santos Silva, Isabel
Severi, Gianluca
Hamann, Ute
Pharoah, Paul
Easton, Douglas F
Chang-Claude, Jenny
Yannoukakos, Drakoulis
Nevanlinna, Heli
Wang, Xianshu
Couch, Fergus J #
Issue Date: Oct-2011
Publisher: Waverly Press
Series Title: Cancer Research vol:71 issue:19 pages:6240-6249
Abstract: Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer. Cancer Res; 71(19); 6240-9. ©2011 AACR.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Laboratory of Experimental Radiotherapy
Laboratory of Translational Genetics (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science