Title: Corticosteroid effects on ventilator-induced diaphragm dysfunction in anesthetized rats depend on the dose administered
Authors: Maes, Karen ×
Agten, Anouk
Smuder, Ashley
Powers, Scott K
Decramer, Marc
Gayan-Ramirez, Ghislaine #
Issue Date: Dec-2010
Publisher: Biomed Central Ltd
Series Title: Respiratory Research vol:11
Article number: 178
Abstract: High dose of corticosteroids has been previously shown to protect against controlled mechanical ventilation (CMV)-induced diaphragmatic dysfunction while inhibiting calpain activation. Because literature suggests that the calpain inhibiting effect of corticosteroid depends on the dose administered, we determined whether lower doses of corticosteroids would also provide protection of the diaphragm during CMV. This may be important for patients undergoing mechanical ventilation and receiving corticosteroids.
ISSN: 1465-993X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pneumology
× corresponding author
# (joint) last author

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