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Title: An ensemble biclustering approach for querying gene expression compendia with experimental lists
Authors: De Smet, Riet
Marchal, Kathleen # ×
Issue Date: Jul-2011
Publisher: Oxford University Press
Series Title: Bioinformatics vol:27 issue:14 pages:1948-1956
Abstract: Motivation: Query-based biclustering techniques allow interrogating a gene expression compendium with a given gene or gene list. They do so by searching for genes in the compendium that have a profile close to the average expression profile of the genes in this query-list. As it can often not be guaranteed that the genes in a long query-list will all be mutually coexpressed, it is advisable to use each gene separately as a query. This approach, however, leaves the user with a tedious post-processing of partially redundant biclustering results. The fact that for each query-gene multiple parameter settings need to be tested in order to detect the 'most optimal bicluster size' adds to the redundancy problem.
ISSN: 1367-4803
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Centre of Microbial and Plant Genetics
× corresponding author
# (joint) last author

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