Frailty in Relation to Variations in Hormone Levels of the Hypothalamic-Pituitary-Testicular Axis in Older Men: Results From the European Male Aging Study

Tajar, Abdelouahid; O'Connell, Matthew DL; Mitnitski, Arnold B; O'Neill, Terence W; Searle, Samuel D; Huhtaniemi, Ilpo T; Finn, Joseph D; Bartfai, Gyoergy; Boonen, Steven; Casanueva, Felipe F; Forti, Gianni; Giwercman, Aleksander; Han, Thang S; Kula, Krzysztof; Labrie, Fernand; Lean, Michael EJ; Pendleton, Neil; Punab, Margus; Silman, Alan J; Vanderschueren, Dirk; Rockwood, Kenneth; Wu, Frederick CW

doi:10.1111/j.1532-5415.2011.03398.x

Frailty in Relation to Variations in Hormone Levels of the Hypothalamic-Pituitary-Testicular Axis in Older Men: Results From the European Male Aging Study

Author:

Tajar, Abdelouahid

O'Connell, Matthew DL ; Mitnitski, Arnold B ; O'Neill, Terence W ; Searle, Samuel D ; Huhtaniemi, Ilpo T ; Finn, Joseph D ; Bartfai, Gyoergy ; Boonen, Steven ; Casanueva, Felipe F ; Forti, Gianni ; Giwercman, Aleksander ; Han, Thang S ; Kula, Krzysztof ; Labrie, Fernand ; Lean, Michael EJ ; Pendleton, Neil ; Punab, Margus ; Silman, Alan J ; Vanderschueren, Dirk ; Rockwood, Kenneth ; Wu, Frederick CW

Keywords:

frailty index, hypothalamic-pituitary-testicular axis, testosterone, epidemiology, emas, late-onset hypogonadism, elderly-men, dehydroepiandrosterone-sulfate, free testosterone, binding globulin, health, women, index, age, serum, Science & Technology, Life Sciences & Biomedicine, Geriatrics & Gerontology, Gerontology, EMAS, DEHYDROEPIANDROSTERONE-SULFATE, FREE TESTOSTERONE, BINDING GLOBULIN, ELDERLY-MEN, HEALTH, INDEX, AGE, HYPOGONADISM, PARADIGM, Aged, Aging, Biomarkers, Cross-Sectional Studies, Dehydroepiandrosterone Sulfate, Europe, Follicle Stimulating Hormone, Frail Elderly, Geriatric Assessment, Health Status Indicators, Humans, Hypothalamo-Hypophyseal System, Hypothalamus, Luteinizing Hormone, Male, Motor Activity, Pituitary Gland, Prospective Studies, Regression Analysis, Sex Hormone-Binding Globulin, Surveys and Questionnaires, Testis, Testosterone, European Male Aging Study Group, 11 Medical and Health Sciences, Geriatrics, 32 Biomedical and clinical sciences, 42 Health sciences, 52 Psychology

Abstract:

OBJECTIVES: To explore the associations between frailty and reproductive axis hormones (as an important regulatory system) in middle aged and older men.