The ESR1 (6q25) Locus Is Associated with Calcaneal Ultrasound Parameters and Radial Volumetric Bone Mineral Density in European Men
Authors:
Holliday, Kate L × Pye, Stephen R Thomson, Wendy Boonen, Steven Borghs, Herman Vanderschueren, Dirk Gielen, Evelien Huhtaniemi, Ilpo T Adams, Judith E Ward, Kate A Bartfai, Gyorgy Casanueva, Felipe Finn, Joseph D Forti, Gianni Giwercman, Aleksander Han, Thang S Kula, Krzysztof Labrie, Fernand Lean, Michael E. J Pendleton, Neil Punab, Margus Wu, Frederick C. W O'Neill, Terence W #
Issue Date:
Jul-2011
Publisher:
Public Library of Sciene
Series Title:
PLoS One vol:6 issue:7 pages:-
Article number:
e22037
Abstract:
Purpose: Genome-wide association studies (GWAS) have identified 6q25, which incorporates the oestrogen receptor alpha gene (ESR1), as a quantitative trait locus for areal bone mineral density (BMDa) of the hip and lumbar spine. The aim of this study was to determine the influence of this locus on other bone health outcomes; calcaneal ultrasound (QUS) parameters, radial peripheral quantitative computed tomography (pQCT) parameters and markers of bone turnover in a population sample of European men.
