Title: A validation of the first genome-wide association study of calcaneus ultrasound parameters in the European Male Ageing Study
Authors: Roshandel, Delnaz ×
Thomson, Wendy
Pye, Stephen R
Boonen, Steven
Borghs, Herman
Vanderschueren, Dirk
Huhtaniemi, Ilpo T
Adams, Judith E
Ward, Kate A
Bartfai, Gyorgy
Casanueva, Felipe
Finn, Joseph D
Forti, Gianni
Giwercman, Aleksander
Han, Thang S
Kula, Krzysztof
Lean, Michael E
Pendleton, Neil
Punab, Margus
Silman, Alan J
Wu, Frederick C
Holliday, Kate L
O'Neill, Terence W #
Issue Date: 28-Jan-2011
Publisher: BioMed Central
Series Title: BMC Medical Genetics vol:12 pages:19
Article number: 19
Abstract: Background: A number of single nucleotide polymorphisms (SNPs) have been associated with broadband ultrasound attenuation (BUA) and speed of sound (SOS) as measured by quantitative ultrasound (QUS) at the calcaneus in the Framingham 100K genome-wide association study (GWAS) but have not been validated in independent studies. The aim of this analysis was to determine if these SNPs are associated with QUS measurements assessed in a large independent population of European middle-aged and elderly men. The association between these SNPs and bone mineral density (BMD) measured using dual-energy X-ray absorptiometry (DXA) was also tested.
ISSN: 1471-2350
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Gerontology and Geriatrics
× corresponding author
# (joint) last author

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