Title: Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging
Authors: Sodero, Alejandro Omar ×
Trovò, Laura
Iannilli, Francesca
Van Veldhoven, Paul P
Dotti, Carlos
Martin, Mauricio G #
Issue Date: Mar-2011
Publisher: Raven Press
Series Title: Journal of Neurochemistry vol:116 issue:5 pages:747-755
Article number: 10.1111/j.1471-4159.2010.07079.x
Abstract: It is well established that memory formation and retention involve the coordinated flow of information from the post-synaptic site of particular neuronal populations to the nucleus, where short and long-lasting modifications of gene expression occur. With age, mnemonic, motor and sensorial alterations occur, and it is believed that extra failures in the mechanisms used for memory formation and storage are the cause of neurodegenerative pathologies like Alzheimer's disease. A prime candidate responsible for damage and loss of function during aging is the accumulation of reactive oxygen species, derived from normal oxidative metabolism. However, dysfunction in the aged brain is not paralleled by an increase in neuronal death, indicative that the brain is better suited to fight against the death signals generated from reactive oxygen species than against loss-of-function stimuli. A main aim of this laboratory is to understand how neurons perform and survive in the constitutive stress background represented by aging. In this report, we summarize our recent findings in relation to survival.
ISSN: 0022-3042
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Lipid Biochemistry and Protein Interactions
Laboratory of Neuronal Differentiation
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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