Title: The application of "click chemistry" for the decoration of 2(1H)-pyrazinone scaffold: Generation of templates
Authors: Kaval, N ×
Ermolat'ev, D
Appukkuttan, P
Dehaen, Wim
Kappe, CO
Van der Eycken, Erik #
Issue Date: Jan-2005
Publisher: Amer chemical soc
Series Title: Journal of combinatorial chemistry vol:7 issue:3 pages:490-502
Abstract: The "click chemistry" approach has been explored on the 2-(1H)-pyrazinone scaffold for the generation of pharmacologically interesting heterocyclic moieties. Huisgen 1,3-dipolar cycloaddition has been evaluated as the key step for the construction of the 1,2,3-triazole ring at the C-3 position of 2-(1H)-pyrazinones. Two different pathways have been successfully evaluated: (1) via C-C or C-O linkage of the acetylenic part to the C-3 position of the 2-(1H)-pyrazinone scaffold or (2) via azide introduction in the C-3 position. The subsequent application of "click chemistry" resulted in the formation of hitherto unknown skeletons. Microwave irradiation has successfully been applied in different steps of the sequence.
ISSN: 1520-4766
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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