Title: Biological activity of CXCL8 forms generated by alternative cleavage of the signal peptide or by aminopeptidase-mediated truncation
Authors: Mortier, Anneleen ×
Berghmans, Nele
Ronsse, Isabelle
Grauwen, Karolien
Stegen, Steve
Van Damme, Jo
Proost, Paul #
Issue Date: 2011
Publisher: Public Library of Sciene
Series Title: PLoS One vol:6 issue:8 pages:e23913
Article number: e23913
Abstract: Posttranslational modification of chemokines is one of the mechanisms that regulate leukocyte migration during inflammation. Multiple natural NH(2)-terminally truncated forms of the major human neutrophil attractant interleukin-8 or CXCL8 have been identified. Although differential activity was reported for some CXCL8 forms, no biological data are available for others.
ISSN: 1932-6203
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Molecular Immunology (Rega Institute)
Clinical and Experimental Endocrinology
× corresponding author
# (joint) last author

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