Title: Synthesis and biological evaluation of some stilbene derivatives
Authors: Karki, Subhas ×
Bhutle, Santosh
Sahoo, Subhas
Reddy, Ratnakar
Balzarini, Jan
De Clercq, Erik
Darji, Satyanarayana #
Issue Date: Nov-2011
Publisher: Birkhäuser Boston
Series Title: Medicinal Chemistry Research vol:20 pages:1349-1356
Abstract: Several trans and cis stilbenes with substitution on the olefinic bridge were synthesized and characterized by IR, NMR and mass spectroscopy in an effort to obtain substances that could be more readily formulated. All the synthesized compounds were screened against Molt4/C8, CEM and L1210 cell lines. None of these compounds were endowed with pronounced cytostatic activity. However, Schiff derivatives emerged as cytostatic agents (IC50: 0.77–10 μg/ml) that deserve further investigation.
ISSN: 1054-2523
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
× corresponding author
# (joint) last author

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