Medicinal Chemistry Research vol:20 pages:1349-1356
Several trans and cis stilbenes with substitution on the olefinic bridge were synthesized and characterized by IR, NMR and mass spectroscopy in an effort to obtain substances that could be more readily formulated. All the synthesized compounds were screened against Molt4/C8, CEM and L1210 cell lines. None of these compounds were endowed with pronounced cytostatic activity. However, Schiff derivatives emerged as cytostatic agents (IC50: 0.77–10 μg/ml) that deserve further investigation.