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Title: Synthesis and evaluation of new linear azo-polymers for colonic targeting
Authors: Van den Mooter, Guy ×
Offringa, M
Kalala, W
Samyn, Celest
Kinget, Renaat #
Issue Date: Jan-1995
Publisher: Editions sante
Series Title: STP Pharma sciences vol:5 issue:1 pages:36-40
Abstract: Copolymers of 4-[4-[(6-hydroxyhexyl)oxy]phenylazo] benzoic acid and 16-hydroxyhexadecanoic acid were prepared by polycondensation and evaluated as materials for colonic targeting. The in vitro degradation of the azo-polymers was performed in sonicated rat coecal content (cell-free extract) containing nicotinamide adenine dinucleotide phosphate, glucose-6-phosphate, glucose-6-phosphate dehydrogenase, and benzyl viologen as the redox mediator. The degradation of the azo-polymers was examined using UV absorption spectrometry and solution viscosimetry. The results of this study clearly demonstrate that the polymers can be degraded by rat bacterial azo-reductase to polymers with lower molecular weight, and may offer opportunities to develop colon-specific drug delivery systems.
ISSN: 1157-1489
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Drug Delivery and Disposition
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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