Title: Myeloid cell differentiation arrest by miR-125b-1 in myelodysplasic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation
Authors: Bousquet, Marina ×
Quelen, Cathy
Rosati, Roberto
Mansat-De Mas, Véronique
La Starza, Roberta
Bastard, Christian
Lippert, Eric
Talmant, Pascaline
Lafage-Pochitaloff, Marina
Leroux, Dominique
Gervais, Carine
Viguié, Franck
Lai, Jean-Luc
Terre, Christine
Beverlo, Berna
Sambani, Costantina
Hagemeijer-Hausman, Anne
Marynen, Peter
Delsol, Georges
Dastugue, Nicole
Mecucci, Cristina
Brousset, Pierre #
Issue Date: Oct-2008
Publisher: Rockefeller univ press
Series Title: Journal of Experimental Medicine vol:205 issue:11 pages:2499-2506
Abstract: Most chromosomal translocations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) involve oncogenes that are either up-regulated or form part of new chimeric genes. The t(2; 11)(p21;q23) translocation has been cloned in 19 cases of MDS and AML. In addition to this, we have shown that this translocation is associated with a strong up-regulation of miR-125b (from 6- to 90-fold). In vitro experiments revealed that miR- 125b was able to interfere with primary human CD34(+) cell differentiation, and also inhibited terminal (monocytic and granulocytic) differentiation in HL60 and NB4 leukemic cell lines. Therefore, miR-125b up-regulation may represent a new mechanism of myeloid cell transformation, and myeloid neoplasms carrying the t(2; 11) translocation define a new clinicopathological entity.
ISSN: 0022-1007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Molecular Genetics Section (-)
× corresponding author
# (joint) last author

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