Title: FOXP1 and PAX5 are rare but recurrent translocations partners in acute lymphoblastic leukemia
Authors: Put, Natalie
Deeren, Dries
Michaux, Lucienne
Vandenberghe, Peter # ×
Issue Date: Aug-2011
Series Title: Cancer Genetics vol:204 issue:8 pages:462-464
Abstract: Here, we report the case of a 57-year-old man, who was diagnosed with B-cell acute lymphoblastic leukemia (B-ALL). His diagnostic workup identified a translocation t(3;9)(p13;p13). This is the fifth case reported to date that involved the forkhead box P1 gene (FOXP1) and paired box gene 5 (PAX5). The PAX5-FOXP1 translocation is a nonrandom aberration, which is recurrent in both childhood and in adult B-ALL, and may contribute to leukemogenesis by blocking differentiation of hematopoietic cells into mature B-cells.
ISSN: 2210-7762
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Laboratory for Genetics of Malignant Disorders
× corresponding author
# (joint) last author

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