ITEM METADATA RECORD
Title: Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
Authors: Fox, Ervin R ×
Young, J Hunter
Dreisbach, Albert W
Keating, Brendan J
Musani, Solomon K
Liu, Kiang
Morrison, Alanna C
Ganesh, Santhi
Kutlar, Abdullah
Ramachandran, Vasan S
Polak, Josef F
Peltonen, Leena
Perola, Markus
Vartiainen, Erkki
Brand, Stefan-Martin
Staessen, Jan A
Wang, Thomas J
Burton, Paul R
Artigas, Maria Soler
Dong, Yanbin
Penman, Alan D
Onland-Moret, N Charlotte
Snieder, Harold
Wang, Xiaoling
Zhu, Haidong
Lohman, Kurt K
Rudock, Megan E
Heckbert, Susan R
Smith, Nicholas L
Wiggins, Kerri L
Shriner, Daniel
Veldre, Gudrun
Cooper, Matthew N
Palmas, Walter
Viigimaa, Margus
Kinra, Sanjay
Prabhakaran, Dorairajan
Tripathy, Vikal
Langefeld, Carl D
Rosengren, Annika
Thelle, Dag S
Corsi, Anna Maria
Singleton, Andrew
Platou, Carl G P
Forrester, Terrence
Rotter, Jerome I
Hilton, Gina
McKenzie, Colin A
Salako, Tunde
Iwai, Naoharu
Kita, Yoshikuni
Ogihara, Toshio
Ohkubo, Takayoshi
Okamura, Tomonori
Org, Elin
Ueshima, Hirotsugu
Umemura, Satoshi
Townsend, Raymond R
Eyheramendy, Susana
Meitinger, Thomas
Wichmann, H-Erich
Cho, Yoon Shin
Kim, Hyung-Lae
Lee, Jong-Young
Scott, James
Hardy, Rebecca
Sehmi, Joban S
Zhang, Weihua
Hedblad, Bo
Doumatey, Ayo P
Nilsson, Peter
Smith, George Davey
Wong, Andrew
Narisu, Narisu
Stancáková, Alena
Raffel, Leslie J
Dahgam, Santosh
Yao, Jie
Kathiresan, Sekar
O'Donnell, Chris
Schwartz, Steven M
Tayo, Bamidele O
Ikram, M Arfan
Longstreth, Will T
Seshadri, Sudha
Shrine, Nick R G
Wain, Louise V
Palmen, Jutta
Morken, Mario A
Swift, Amy J
Laitinen, Jaana
Prokopenko, Inga
Zitting, Paavo
Mosley, Thomas H
Cooper, Jackie A
Humphries, Steve E
Danesh, John
Rasheed, Asif
Vitart, Veronique
Goel, Anuj
Hamsten, Anders
Watkins, Hugh
Bakker, Stephan J L
van Gilst, Wiek H
Janipalli, Charles s
Lyon, Helen N
Mani, K Radha
Yajnik, Chittaranjan S
Hofman, Albert
Braund, Peter S
Mattace-Raso, Francesco U S
Oostra, Ben A
Demirkan, Ayse
Isaacs, Aaron
Rivadeneira, Fernando
Lakatta, Edward G
Orru, Marco
Kang, Sun J
Scuteri, Angelo
Ala-Korpela, Mika
Kuznetsova, Tatiana
Kangas, Antti J
Lyytikäinen, Leo-Pekka
Soininen, Pasi
Tukiainen, Taru
Würz, Peter
Ong, Rick Twee-Hee
Dörr, Marcus
Kroemer, Heyo K
Rotimi, Charles N
Völker, Uwe
Fabsitz, Richard R
Völzke, Henry
Galan, Pilar
Hercberg, Serge
Lathrop, Mark
Zelenika, Diana
Deloukas, Panos
Mangino, Massimo
Spector, Tim D
Zhai, Guangju
Cooper, Richard S
Uiterwaal, Cuno S P M
Meschia, James F
Nalls, Michael A
Sharma, Pankaj
Terzic, Janos
Kumar, M J Kranthi
Denniff, Matthew
Zukowska-Szczechowska, Ewa
Wagenknecht, Lynne E
Fowkes, F Gerald R
Charchar, Fadi J
Campbell, Harry
Franceschini, Nora
Schwarz, Peter E H
Hayward, Caroline
Guo, Xiuqing
Bots, Michiel L
Brand, Eva
Samani, Nilesh j
Polasek, Ozren
Talmud, Philippa J
Nyberg, Fredrik
Ludwig, Barbara
Kuh, Diana
Curb, J David
Laan, Maris
Hveem, Kristian
Palmer, Lyle J
van der Schouw, Yvonne T
Casas, Juan P
Mohlke, Karen L
Vineis, Paolo
Raitakari, Olli
Tomaszewski, Maciej
Wong, Tien Y
Tai, E Shyong
Martin, Lisa W
Laakso, Markku
Rao, Dabeeru C
Harris, Tamara B
Morris, Richard W
Dominiczak, Anna F
Kivimaki, Mika
Marmot, Michael G
Tzoulaki, Ioanna
Miki, Tetsuro
Saleheen, Danish
Chandak, Giriraj R
Eaton, Charles B
Coresh, Josef
Navis, Gerjan
Salomaa, Veikko
Han, Bok-Ghee
Kooner, Jaspal S
Melander, Olle
Palmer, Nicholette D
Ridker, Paul M
Bandinelli, Stefania
Gyllensten, Ulf B
Wright, Alan F
Kardia, Sharon L R
Wilson, James F
Ferrucci, Luigi
Farrall, Martin
Tuomilehto, Jaakko
Pramstaller, Peter P
CARDIoGRAM consortium
Elosua, Roberto
Soranzo, Nicole
Sijbrands, Eric J G
Altshuler, David
Loos, Ruth J F
Taylor, Herman A
Shuldiner, Alan R
Gieger, Christian
Meneton, Pierre
Uitterlinden, Andre G
CKDGen consortium
Wareham, Nicholas J
Gudnason, Vilmundur
Rettig, Rainer
Uda, Manuela
Strachan, David P
Witteman, Jacqueline C M
Caulfield, Mark J
Hartikainen, Anna-Liisa
Beckmann, Jacques S
Boerwinkle, Eric
KidneyGen consortium
Boehnke, Michael
Larson, Martin G
Järvelin, Marjo-Riitt
Psaty, Bruce M
Abecasis, Gonçalo R
Elliott, Paul
van Duijn, Cornelia M
Ehret, Georg B
Newton-Cheh, Christopher
Johnson, Toby
EchoGen consortium
International Consortium for Blood Pressure Genome-wide Association Studies (ICBP-GWAS)
Chakravarti, Aravinda
Zhu, Xiaofeng
Levy, Daniel
Munroe, Patricia B
Rice, Kenneth M
Bochud, Murielle
Johnson, Andrew D
Chasman, Daniel I
Smith, Albert V
Dries, Daniel L
Tobin, Martin D
Verwoert, Germaine C
Hwang, Shih-Jen
Pihur, Vasyl
Vollenweider, Peter
O'Reilly, Paul F
Amin, Najaf
Bragg-Gresham, Jennifer L
Teumer, Alexander
Glazer, Nicole L
CHARGE-HF consortium
Launer, Lenore
Zhao, Jing Hua
Aulchenko, Yurii
Heath, Simon
Sõber, Siim
Parsa, Afshin
Luan, Jian'an
Arora, Pankaj
Dehghan, Abbas
Zhang, Feng
Aspelund, Thor
Lucas, Gavin
Hicks, Andrew A
Jackson, Anne U
Peden, John F
Tanaka, Toshiko
Wild, Sarah H
Rudan, Igor
Igl, Wilmar
Milaneschi, Yuri
Parker, Alex N
Garcia, Melissa
Fava, Cristiano
Chambers, John C
Kumari, Meena
van der Harst, Pim
Kao, Wen Hong Linda
Sjögren, Marketa
Vinay, D G
Alexander, Myriam
Tabara, Yasuharu
Shaw-Hawkins, Sue
Chang, Yen-Pei C
Whincup, Peter H
Liu, Yongmei
Shi, Gang
Kuusisto, Johanna
Seielstad, Mark
Sim, Xueling
Nguyen, Khanh-Dung Hoang
Lehtimäki, Terho
Matullo, Giuseppe
Wu, Ying
O'Connell, Jeffrey R
Gaunt, Tom R
Steinle, Nanette I
Grobbee, Diederick E
Arking, Dan E
Hernandez, Dena
Najjar, Samer
Farlow, Deborah N
McArdle, Wendy L
Hadley, David
Brown, Morris J
Connell, John M
Hingorani, Aroon D
Day, Ian N M
Lawlor, Debbie A
Beilby, John P
Lawrence, Robert W
Clarke, Robert
Redline, Susan
Collins, Rory
Hopewell, Jemma C
Ongen, Halit
Bis, Joshua C
Kähönen, Mika
Viikari, Jorma
Adair, Linda S
Lee, Nanette R
Chen, Ming-Huei
Olden, Matthias
Adeyemo, Adebowale
Pattaro, Cristian
Hoffman Bolton, Judith A
Köttgen, Anna
Bergmann, Sven
Mooser, Vincent
Chaturvedi, Nish
Frayling, Timothy M
Islam, Muhammad
Jafar, Tazeen H
Erdmann, Jeanette
Hirschorn, Joel N
Kulkarni, Smita R
Bornstein, Stefan R
Grässler, Jürgen
Groop, Leif
Voight, Benjamin F
Kettunen, Johannes
Howard, Philip
Taylor, Andrew
Guarrera, Simonetta
Ricceri, Fulvio
Sun, Yan V
Emilsson, Valur
Plump, Andrew
Barroso, Inês
Khaw, Kay-Tee
Weder, Alan B
Hunt, Steven C
Bergman, Richard N
Collins, Francis S
Bonnycastle, Lori L
Scott, Laura J
Wyatt, Sharon B
Stringham, Heather M #
Issue Date: Jun-2011
Publisher: IRL Press
Series Title: Human Molecular Genetics vol:20 issue:11 pages:2273-2284
Abstract: The prevalence of hypertension in African Americans (AAs) is higher than in other US groups; yet, few have performed genome-wide association studies (GWASs) in AA. Among people of European descent, GWASs have identified genetic variants at 13 loci that are associated with blood pressure. It is unknown if these variants confer susceptibility in people of African ancestry. Here, we examined genome-wide and candidate gene associations with systolic blood pressure (SBP) and diastolic blood pressure (DBP) using the Candidate Gene Association Resource (CARe) consortium consisting of 8591 AAs. Genotypes included genome-wide single-nucleotide polymorphism (SNP) data utilizing the Affymetrix 6.0 array with imputation to 2.5 million HapMap SNPs and candidate gene SNP data utilizing a 50K cardiovascular gene-centric array (ITMAT-Broad-CARe [IBC] array). For Affymetrix data, the strongest signal for DBP was rs10474346 (P= 3.6 × 10(-8)) located near GPR98 and ARRDC3. For SBP, the strongest signal was rs2258119 in C21orf91 (P= 4.7 × 10(-8)). The top IBC association for SBP was rs2012318 (P= 6.4 × 10(-6)) near SLC25A42 and for DBP was rs2523586 (P= 1.3 × 10(-6)) near HLA-B. None of the top variants replicated in additional AA (n = 11 882) or European-American (n = 69 899) cohorts. We replicated previously reported European-American blood pressure SNPs in our AA samples (SH2B3, P= 0.009; TBX3-TBX5, P= 0.03; and CSK-ULK3, P= 0.0004). These genetic loci represent the best evidence of genetic influences on SBP and DBP in AAs to date. More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity.
URI: 
ISSN: 0964-6906
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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