ITEM METADATA RECORD
Title: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Authors: The International Consortium for Blood Pressure Genome-Wide Association Studies ×
Ehret, Georg B
Munroe, Patricia B
Rice, Kenneth M
Bochud, Murielle
Johnson, Andrew D
Chasman, Daniel I
Smith, Albert V
Tobin, Martin D
Verwoert, Germaine C
Hwang, Shih-Jen
Okamura, Tomonori
Ueshima, Hirotsugu
Umemura, Satoshi
Eyheramendy, Susana
Meitinger, Thomas
Wichmann, H-Erich
Shin Cho, Yoon
Kim, Hyung-Lae
Lee, Jong-Young
Hua Zhao, Jing
Clarke, Robert
Scott, James
Sehmi, Joban S
Zhang, Weihua
Hedblad, Bo
Nilsson, Peter
Davey Smith, George
Wong, Andrew
Narisu, Narisu
StanĨáková, Alena
Raffel, Leslie J
Hopewell, Jemma C
Aulchenko, Yurii
Yao, Jie
Kathiresan, Sekar
O'Donnell, Christopher J
Schwartz, Stephen M
Arfan Ikram, M
Longstreth Jr, W T
Mosley, Thomas H
Seshadri, Sudha
Shrine, Nick R G
Ongen, Halit
Wain, Louise V
Heath, Simon
Morken, Mario A
Swift, Amy J
Laitinen, Jaana
Prokopenko, Inga
Zitting, Paavo
Cooper, Jackie A
Humphries, Steve E
Danesh, John
Dreisbach, Albert W
Rasheed, Asif
Goel, Anuj
Sõber, Siim
Hamsten, Anders
Watkins, Hugh
Bakker, Stephan J L
van Gilst, Wiek H
Janipalli, Charles S
Radha Mani, K
Yajnik, Chittaranjan S
Hunter Young, J
Hofman, Albert
Mattace-Raso, Francesco U S
Oostra, Ben A
Parsa, Afshin
Demirkan, Ayse
Isaacs, Aaron
Rivadeneira, Fernando
Lakatta, Edward G
Orru, Marco
Scuteri, Angelo
Bis, Joshua C
Ala-Korpela, Mika
Kangas, Antti J
Lyytikäinen, Leo-Pekka
Soininen, Pasi
Luan, Jian'an
Tukiainen, Taru
Würtz, Peter
Twee-Hee Ong, Rick
Dörr, Marcus
Kroemer, Heyo K
Kähönen, Mika
Völker, Uwe
Völzke, Henry
Galan, Pilar
Hercberg, Serge
Lathrop, Mark
Arora, Pankaj
Zelenika, Diana
Deloukas, Panos
Mangino, Massimo
Spector, Tim D
Viikari, Jorma
Zhai, Guangju
Meschia, James F
Nalls, Michael A
Sharma, Pankaj
Terzic, Janos
Kranthi Kumar, M V
Dehghan, Abbas
Denniff, Matthew
Zukowska-Szczechowska, Ewa
Wagenknecht, Lynne E
Adair, Linda S
Gerald R Fowkes, F
Charchar, Fadi J
Schwarz, Peter E H
Hayward, Caroline
Guo, Xiuqing
Rotimi, Charles
Bots, Michiel L
Zhang, Feng
Brand, Eva
Samani, Nilesh J
Lee, Nanette R
Polasek, Ozren
Talmud, Philippa J
Nyberg, Fredrik
Kuh, Diana
Laan, Maris
Hveem, Kristian
Palmer, Lyle J
van der Schouw, Yvonne T
Lucas, Gavin
Casas, Juan P
Pihur, Vasyl
Mohlke, Karen L
Vineis, Paolo
Raitakari, Olli
Ganesh, Santhi K
Wong, Tien Y
Shyong Tai, E
Cooper, Richard S
Laakso, Markku
Rao, Dabeeru C
Hicks, Andrew A
Chen, Ming-Huei
Harris, Tamara B
Morris, Richard W
Dominiczak, Anna F
Kivimaki, Mika
Marmot, Michael G
Miki, Tetsuro
Saleheen, Danish
Chandak, Giriraj R
Coresh, Josef
Navis, Gerjan
Olden, Matthias
Jackson, Anne U
Salomaa, Veikko
Han, Bok-Ghee
Zhu, Xiaofeng
Kooner, Jaspal S
Melander, Olle
Ridker, Paul M
Bandinelli, Stefania
Gyllensten, Ulf B
Wright, Alan F
Pattaro, Cristian
Wilson, James F
Peden, John F
Ferrucci, Luigi
Farrall, Martin
Tuomilehto, Jaakko
Pramstaller, Peter P
Elosua, Roberto
Soranzo, Nicole
Sijbrands, Eric J G
Altshuler, David
Hoffman Bolton, Judith A
Loos, Ruth J F
Shuldiner, Alan R
Tanaka, Toshiko
Gieger, Christian
Meneton, Pierre
Uitterlinden, Andre G
Wareham, Nicholas J
Gudnason, Vilmundur
Rotter, Jerome I
Rettig, Rainer
Köttgen, Anna
Uda, Manuela
Strachan, David P
Witteman, Jacqueline C M
Wild, Sarah H
Hartikainen, Anna-Liisa
Beckmann, Jacques S
Boerwinkle, Eric
Vasan, Ramachandran S
Boehnke, Michael
Larson, Martin G
Bergmann, Sven
Järvelin, Marjo-Riitta
Psaty, Bruce M
Abecasis, Gonçalo R
Chakravarti, Aravinda
Rudan, Igor
Elliott, Paul
van Duijn, Cornelia M
Newton-Cheh, Christopher
Levy, Daniel
Caulfield, Mark J
Mooser, Vincent
Johnson, Toby
Igl, Wilmar
Milaneschi, Yuri
Parker, Alex N
Fava, Cristiano
Chambers, John C
Fox, Ervin R
Kumari, Meena
Jin Go, Min
van der Harst, Pim
Chaturvedi, Nish
Hong Linda Kao, Wen
Sjögren, Marketa
Vinay, D G
Alexander, Myriam
Tabara, Yasuharu
Shaw-Hawkins, Sue
Whincup, Peter H
Liu, Yongmei
Shi, Gang
Kuusisto, Johanna
Frayling, Timothy M
Tayo, Bamidele
Seielstad, Mark
Sim, Xueling
Hoang Nguyen, Khanh-Dung
Lehtimäki, Terho
Matullo, Giuseppe
Wu, Ying
Gaunt, Tom R
Charlotte Onland-Moret, N
Cooper, Matthew N
Islam, Muhammad
Platou, Carl G P
Org, Elin
Hardy, Rebecca
Dahgam, Santosh
Palmen, Jutta
Vitart, Veronique
Braund, Peter S
Kuznetsova, Tatiana
Uiterwaal, Cuno S P M
Adeyemo, Adebowale
Vollenweider, Peter
Palmas, Walter
Campbell, Harry
Ludwig, Barbara
Tomaszewski, Maciej
Tzoulaki, Ioanna
Palmer, Nicholette D
Aspelund, Thor
Garcia, Melissa
Chang, Yen-Pei C
O'Connell, Jeffrey R
Jafar, Tazeen H
Steinle, Nanette I
Grobbee, Diederick E
Arking, Dan E
Kardia, Sharon L
Morrison, Alanna C
Hernandez, Dena
Najjar, Samer
McArdle, Wendy L
Hadley, David
Brown, Morris J
Erdmann, Jeanette
Connell, John M
Hingorani, Aroon D
Day, Ian N M
Lawlor, Debbie A
Beilby, John P
Lawrence, Robert W
Kulkarni, Smita R
Bornstein, Stefan R
Grässler, Jürgen
Groop, Leif
Voight, Benjamin F
Kettunen, Johannes
Howard, Philip
Taylor, Andrew
O'Reilly, Paul F
Guarrera, Simonetta
Ricceri, Fulvio
Emilsson, Valur
Plump, Andrew
Barroso, Inês
Khaw, Kay-Tee
Weder, Alan B
Hunt, Steven C
Sun, Yan V
Bergman, Richard N
Amin, Najaf
Collins, Francis S
Bonnycastle, Lori L
Scott, Laura J
Stringham, Heather M
Peltonen, Leena
Perola, Markus
Vartiainen, Erkki
Brand, Stefan-Martin
Staessen, Jan A
Wang, Thomas J
Bragg-Gresham, Jennifer L
Burton, Paul R
Soler Artigas, Maria
Dong, Yanbin
Snieder, Harold
Wang, Xiaoling
Zhu, Haidong
Lohman, Kurt K
Rudock, Megan E
Heckbert, Susan R
Smith, Nicholas L
Teumer, Alexander
Wiggins, Kerri L
Doumatey, Ayo
Shriner, Daniel
Veldre, Gudrun
Viigimaa, Margus
Kinra, Sanjay
Prabhakaran, Dorairaj
Tripathy, Vikal
Langefeld, Carl D
Rosengren, Annika
Glazer, Nicole L
Thelle, Dag S
Maria Corsi, Anna
Singleton, Andrew
Forrester, Terrence
Hilton, Gina
McKenzie, Colin A
Salako, Tunde
Iwai, Naoharu
Kita, Yoshikuni
Ogihara, Toshio
Launer, Lenore
Ohkubo, Takayoshi #
Issue Date: Sep-2011
Publisher: Nature Publishing Group
Series Title: Nature vol:478 issue:7367 pages:103-109
Article number: 10.1038/nature10405
Abstract: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
URI: 
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hypertension and Cardiovascular Epidemiology
× corresponding author
# (joint) last author

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