Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians
Meex, Steven J R × van Greevenbroek, Marleen M J Ayoubi, Torik Vlietinck, Robert van Vliet-Ostaptchouk, Jana V Hofker, Martin H Vermeulen, Vicky M M-J Schalkwijk, Casper G Feskens, Edith J M Boer, Jolanda M A Stehouwer, Coen D A van der Kallen, Carla J H de Bruin, Tjerk W A #
Issued for the Endocrine Society by the Williams & Wilkins Co.
Journal of Clinical Endocrinology & Metabolism vol:92 issue:7 pages:2720-2725
Activating transcription factor 6 (ATF6) is critical for initiation and full activation of the unfolded protein response. An association between genetic variation in ATF6 and type 2 diabetes (DM2) was recently reported in Pima Indians.