Systemic Complement Activation in Deceased Donors Is Associated With Acute Rejection After Renal Transplantation in the Recipient
Damman, Jeffrey × Seelen, Marc A Moers, Cyril Daha, Mohamed R Rahmel, Axel Leuvenink, Henri G Paul, Andreas Pirenne, Jacques Ploeg, Rutger J #
Lippincott Williams & Wilkins
Transplantation vol:92 issue:2 pages:163-169
Background. Acute rejection after renal transplantation has been shown to be negatively associated with long-term graft survival. Identifying donor factors that are associated with acute rejection in the recipient could help to a better understanding of the relevant underlying processes that lead to graft injury. Complement activation has been shown to be an important mediator of renal transplant related injury. In this study, we analyzed the effect of systemic complement activation in deceased donors before transplantation of their kidneys on posttransplant outcome in the recipient.