Title: Differential anthracycline sensitivity in two related human colon carcinoma cell lines expressing similar levels of P-glycoprotein
Authors: Boquete, A L ×
Vargas Roig, L
López, G A
Gude, R
Binda, Maria
González, A D
Ciocca, D R
Bonfil, R D #
Issue Date: Apr-2001
Publisher: Elsevier
Series Title: Cancer Letters vol:165 issue:1 pages:111-116
Abstract: Chemosensitivity of the human colon carcinoma HCT-15 cell line to 4'-epidoxorubicin proved to be 100-fold higher than that of its variant HCT-15 EDR. Confocal scanning microscopy showed significant less drug accumulation in HCT-15 EDR. A 2-fold increase in hsp27 expression was found in HCT-15 EDR, with no alteration in hsp70. The expression of the drug exporter Pgp was similar in both cell lines, despite the lower drug accumulation shown by HCT-15 EDR in respect to HCT-15. Other molecules implicated in the acquisition of enhanced chemoresistance or a more active Pgp variant present in HCT-15 EDR, could explain the phenomenon.
ISSN: 0304-3835
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
× corresponding author
# (joint) last author

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