ITEM METADATA RECORD
Title: Genome-wide association study identifies five new schizophrenia loci
Authors: The Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium ×
Ripke, Stephan
Sanders, Alan R
Kendler, Kenneth S
Sklar, Pamela
Levinson, Douglas F
Lin, Dan-Yu
Holmans, Peter A
Duan, Jubao
Ophoff, Roel A
Scolnick, Edward
Andreassen, Ole A
Corvin, Aiden
Cichon, Sven
Gurling, Hugh
St Clair, David
Werge, Thomas
Rujescu, Dan
Blackwood, Douglas H R
Purcell, Shaun
Pato, Carlos N
Dudbridge, Frank
Malhotra, Anil K
Rossin, Lizzy
Neale, Benjamin M
Posthuma, Danielle
Visscher, Peter M
Fanous, Ayman
Stefansson, Hreinn
Ruderfer, Douglas M
Steinberg, Stacy
Golimbet, Vera
De Hert, Marc
Mowry, Bryan J
Jönsson, Erik G
Bitter, István
Tosato, Sarah
Pietiläinen, Olli P H
Agartz, Ingrid
Collier, David A
Albus, Margot
Alexander, Madeline
Amdur, Richard L.
Amin, Farooq
Bass, Nicholas
Bergen, Sarah E.
Black, Donald W.
Borglum, Anders D.
Brown, Matthew A.
Bruggeman, Richard
Buccola, Nancy G.
Byerley, William F.
Cahn, Wiepke
Cantor, Rita M.
Carr, Vaughan J.
Catts, Stanley V.
Choudhury, Khalid
Cloninger, C. Robert
Cormican, Paul
Craddock, Nicholas
Danoy, Patrick A.
Datta, Susmita
de Haan, Lieuwe
Demontis, Ditte
Dikeos, Dimitris
Djurovic, Srdjan
Donnelly, Peter
Donohoe, Gary
Duong, Linh
Dwyer, Sarah
Fink-Jensen, Anders
Freedman, Robert
Freimer, Nelson B.
Friedl, Marion
Georgieva, Lyudmila
Giegling, Ina
Gill, Michael
Glenthoj, Birte
Godard, Stephanie
Hamshere, Marian
Hansen, Mark
Hansen, Thomas
Hartmann, Annette M.
Henskens, Frans A.
Hougaard, David M.
Hultman, Christina M.
Ingason, Andrés
Jablensky, Assen V.
Jakobsen, Klaus D.
Jay, Maurice
Jürgens, Gesche
Kahn, René S.
Keller, Matthew C.
Kenis, Gunter
Kenny, Elaine
Kim, Yunjung
Kirov, George K.
Honnerth, Heike
Konte, Bettina
Krabbendam, Lydia
Krasucki, Robert
Lasseter, Virginia K.
Laurent, Claudine
Lawrence, Jacob
Lencz, Todd
Lerer, F. Bernard
Liang, Kung-Yee
Lichtenstein, Paul
Lieberman, Jeffrey A.
Linszen, Don H.
Lönnqvist, Jouko
Loughland, Carmel M.
Maclean, Alan W.
Maher, Brion S.
Maier, Wolfgang
Mallet, Jacques
Malloy, Pat
Mattheisen, Manuel
Mattingsdal, Morten
McGhee, Kevin A.
McGrath, John J.
McIntosh, Andrew
McLean, Duncan E.
McQuillin, Andrew
Melle, Ingrid
Michie, Patricia T.
Milanova, Vihra
Morris, Derek W.
Mors, Ole
Mortensen, Preben B.
Moskvina, Valentina
Muglia, Pierandrea
Myin-Germeys, Inez
Nertney, Deborah A.
Nestadt, Gerald
Nielsen, Jimmi
Nikolov, Ivan
Nordentoft, Merete
Norton, Nadine
Nöthen, Markus M.
O'Dushlaine, Colm T.
Olincy, Ann
Olsen, Line
O'Neill, F. Anthony
Orntoft, Torben F.
Owen, Michael J.
Pantelis, Christos
Papadimitriou, George
Pato, Michele T.
Peltonen, Leena
Petursson, Hannes
Pickard, Ben
Pimm, Jonathan
Pulver, Ann E.
Puri, Vinay
Quested, Digby
Quinn, Emma M.
Rasmussen, Henrik B.
Réthelyi, Janos
Ribble, Robert
Rietschel, Marcella
Riley, Brien P.
Ruggeri, Mirella
Schall, Ulrich
Schulze, Thomas G.
Schwab, Sibylle G.
Scott, Rodney J.
Shi, Jianxin
Sigurdsson, Engilbert
Silverman, Jeremy M.
Spencer, Chris C.A.
Stefansson, Kari
Strange, Amy
Strengman, Eric
Stroup, T. Scott
Suvisaari, Jaana
Terenius, Lars
Thirumalai, Srinivasa
Timm, Sally
Toncheva, Draga
van den Oord, Edwin
Thygesen, Johan H
van Os, Jim
van Winkel, Ruud
Veldink, Jan
Walsh, Dermot
Wang, August G.
Wiersma, Durk
Wildenauer, Dieter B.
Williams, Hywel J.
Williams, Nigel M.
Wormley, Brandon
Zammit, Stan
Sullivan, Patrick F
O'Donovan, Michael C
Daly, Mark J
Gejman, Pablo V #
Issue Date: Sep-2011
Publisher: Nature Publishing Group
Series Title: Nature Genetics vol:43 issue:10 pages:969-976
Article number: 10.1038/ng.940
Abstract: We examined the role of common genetic variation in schizophrenia in a genome-wide association study of substantial size: a stage 1 discovery sample of 21,856 individuals of European ancestry and a stage 2 replication sample of 29,839 independent subjects. The combined stage 1 and 2 analysis yielded genome-wide significant associations with schizophrenia for seven loci, five of which are new (1p21.3, 2q32.3, 8p23.2, 8q21.3 and 10q24.32-q24.33) and two of which have been previously implicated (6p21.32-p22.1 and 18q21.2). The strongest new finding (P = 1.6 × 10(-11)) was with rs1625579 within an intron of a putative primary transcript for MIR137 (microRNA 137), a known regulator of neuronal development. Four other schizophrenia loci achieving genome-wide significance contain predicted targets of MIR137, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)).
ISSN: 1061-4036
Publication status: published
KU Leuven publication type: IT
Appears in Collections:University Centre Sint Jozef (-)
Research Group Psychiatry
× corresponding author
# (joint) last author

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