Title: Developmental regulation of Foxp3 expression during ontogeny
Authors: Fontenot, JD ×
Dooley, James
Farr, AG
Rudensky, AY #
Issue Date: Oct-2005
Publisher: Rockefeller Institute for Medical Research
Series Title: Journal of Experimental Medicine vol:202 issue:7 pages:901-906
Abstract: Thymectomy of neonatal mice can result in the development of autoimmune pathology. It has been proposed that thymic output of regulatory T (T reg) cells is delayed during ontogeny and that the development of autoimmune disease in neonatally thymectomized mice is caused by the escape of self-reactive T cells before thymectomy without accompanying T reg cells. However, the kinetics of T reg cell production within the thymus during ontogeny has not been assessed. We demonstrate that the development of Foxp3-expressing T reg cells is substantially delayed relative to nonregulatory thymocytes during ontogeny. Based on our data, we speculate that induction of Foxp3 in developing thymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla.
ISSN: 0022-1007
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity (VIB-KU Leuven Center for Brain & Disease Research)
× corresponding author
# (joint) last author

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