Title: Microwave assisted organic synthesis (MAOS) of small molecules as potential HIV-1 integraseiInhibitors
Authors: Ferro, Stefania ×
Grazia, Sara De
De Luca, Laura
Gitto, Rosaria
Faliti, Caterina Elisa
Debyser, Zeger
Chimirri, Alba #
Issue Date: Aug-2011
Series Title: Molecules vol:16 issue:8 pages:6858-6870
Abstract: Integrase (IN) represents a clinically validated target for the development of antivirals against human immunodeficiency virus (HIV). In recent years our research group has been engaged in the stucture-function study of this enzyme and in the development of some three-dimensional pharmacophore models which have led to the identification of a large series of potent HIV-1 integrase strand-transfer inhibitors (INSTIs) bearing an indole core. To gain a better understanding of the structure-activity relationships (SARs), herein we report the design and microwave-assisted synthesis of a novel series of 1-H-benzylindole derivatives.
ISSN: 1420-3049
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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