Title: Asymmetric Synthesis of New beta-Lactam Lipopeptides as Bacterial Signal Peptidase I Inhibitors
Authors: Crauste, Celine
Froeyen, Mathy
Anne, Jozef
Herdewijn, Piet # ×
Issue Date: Jul-2011
Publisher: Wiley-VCH
Series Title: European Journal of Organic Chemistry issue:19 pages:3437-3449
Abstract: The transmembrane bacterial enzyme, signal peptidase I, is recognized as being a promising target for reducing the emergence of drug resistance. The asymmetric synthesis and the biological evaluation of original beta-lactam lipopeptides have been performed to discover potent signal peptidase inhibitors. The importance of the azetidinone motif of these lipopeptides has been demonstrated and can serve as a starting point to exploit and improve the reactivity of the beta-lactam in peptidomimetics.
ISSN: 1434-193X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Medicinal Chemistry (Rega Institute)
Department of Pharmaceutical & Pharmacological Sciences - miscellaneous
× corresponding author
# (joint) last author

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