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Title: Study of the reaction of specifically substituted 2H-1,4 oxazin-2-ones with acetylenic compounds as a potential route for specific 3- or 4-pyridinecarboxylates
Authors: Lux, G ×
Wu, XJ
Toppet, Suzanne
Hoornaert, Georges #
Issue Date: Jan-1997
Publisher: Comite van beheer van het bulletin vzw
Series Title: Bulletin des societes chimiques belges vol:106 issue:9-10 pages:623-630
Abstract: Cycloaddition-elimination reactions between 3,5-dichloro-2H-1,4-oxazin-2-one and ethyl 4-hydroxyalkynoates have been studied. 4,6-Dichlorofuro[3,4-c]pyridinie-3(1N)ones have been generated, dechlorinated or transformed into the corresponding 3-pyridinecarboxylates. As the regioisomeric lactones and the corresponding 4-pyridinecarboxylates cannot be realised in this way, the synthesis of a 3-tributylstannyloxazinone and the regiochemistry of the cycloaddition with methyl propiolate has been studied. This route is shown to be inefficient for the generation of biologically interesting 4-pyridinecarboxylates.
ISSN: 0037-9646
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
Chemistry - miscellaneous
× corresponding author
# (joint) last author

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