ITEM METADATA RECORD
Title: Understanding the genetic regulation of IgE production
Authors: Altin, John ×
Shen, Chong
Liston, Adrian #
Issue Date: Jul-2010
Publisher: Harcourt Publishers
Series Title: Blood Reviews vol:24 issue:4-5 pages:163-169
Abstract: Immunoglobulin E (IgE) is a key mediator of anti-parasitic and anti-tumour immunity. However it is also a critical component of atopic and autoimmune diseases, and elevated serum IgE levels are a common indicator of immune dysregulation. In this review we survey the literature on genetic associations of elevated IgE in humans and mice. We find that defects in a limited number of pathways explain the majority of gene associations with IgE. Commonly, elevated IgE is associated with defects in Th bias and B cell class switching, severe T cell tolerance defects and defects in immunity at the host-environment interface. These genetic data demonstrate the mechanisms of control over IgE production and the manner in which they can be circumvented. (C) 2010 Elsevier Ltd. All rights reserved.
URI: 
ISSN: 0268-960X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Genetics of Autoimmunity
Laboratory of Clinical Immunology
× corresponding author
# (joint) last author

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