Title: Pulmonary exacerbation: towards a definition for use in clinical trials. Report from the EuroCareCF Working Group on outcome parameters in clinical trials
Authors: Bilton, D ×
Canny, G
Conway, S
Dumcius, S
Hjelte, L
Proesmans, Marijke
Tümmler, B
Vavrova, V
De Boeck, Christiane #
Issue Date: Jun-2011
Series Title: Journal of Cystic Fibrosis vol:10 issue:Suppl 2 pages:S79-S81
Abstract: Pulmonary exacerbations represent a key outcome variable in clinical trials of cystic fibrosis (CF). As there is variation in the trigger for use of intravenous antibiotics compared to the use of oral antibiotics or new nebulised therapy for treatment of exacerbations, the consensus view is that use of intravenous antibiotics cannot be regarded as the key defining character for an exacerbation on its own. The consensus view is that the clinical need for additional treatment as indicated by a recent change in clinical parameters provides the best definition of an exacerbation. Which parameters to include as well as the problems associated with the use of scoring systems and symptom clusters are being discussed.
ISSN: 1569-1993
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pediatric Pulmonology Section (-)
Organ Systems (+)
× corresponding author
# (joint) last author

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