Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization
Roberts, Scott × Narisawa, Sonoko Harmey, Dympna Millán, José Luis Farquharson, Colin #
Blackwell Science, Inc.
Journal of Bone and Mineral Research vol:22 issue:4 pages:617-27
PHOSPHO1 is a phosphatase highly expressed in bone. We studied its functional involvement in mineralization through the use of novel small molecule inhibitors. PHOSPHO1 expression was present within matrix vesicles, and inhibition of enzyme action caused a decrease in the ability of matrix vesicles to calcify.