A Model of Ex Vivo Perfusion of Porcine Donor Lungs Injured by Gastric Aspiration: A Step Towards Pretransplant Reconditioning

Meers, Caroline; Tsagkaropoulos, Sokratis; Wauters, Shana; Verbeken, Erik; Vanaudenaerde, Bart; Scheers, Hans; Verleden, Geert; Van Raemdonck, Dirk

doi:10.1016/j.jss.2011.05.015

A Model of Ex Vivo Perfusion of Porcine Donor Lungs Injured by Gastric Aspiration: A Step Towards Pretransplant Reconditioning

Author:

Meers, Caroline

Tsagkaropoulos, Sokratis ; Wauters, Shana ; Verbeken, Erik ; Vanaudenaerde, Bart ; Scheers, Hans ; Verleden, Geert ; Van Raemdonck, Dirk

Keywords:

lung transplantation, lung injury, ex vivo lung perfusion, gastric aspiration, heart-beating donors, transplantation, experience, criteria, Science & Technology, Life Sciences & Biomedicine, Surgery, HEART-BEATING DONORS, TRANSPLANTATION, EXPERIENCE, CRITERIA, Animals, Blood Pressure, Lung, Lung Injury, Lung Transplantation, Male, Perfusion, Pneumonia, Aspiration, Pulmonary Circulation, Swine, Tissue Donors, Transplantation Conditioning, 1103 Clinical Sciences, 3202 Clinical sciences

Abstract:

Background. Evidence of aspiration remains a major reason for declining donor lungs contributing to current organ shortage. The aim of the present ex vivo lung perfusion (EVLP) study was to compare lungs injured by gastric juice (GJ) with normal lungs.