Title: Human memory B lymphocyte subsets fulfill distinct roles in the anti-polysaccharide and anti-protein immune response
Authors: Moens, Leen
Wuyts, Margareta
Meyts, Isabelle
De Boeck, Christiane
Bossuyt, Xavier # ×
Issue Date: Oct-2008
Publisher: American Association of Immunologists
Series Title: Journal of Immunology vol:181 issue:8 pages:5306-5312
Abstract: There is controversy on the role of IgM memory and switched memory B lymphocytes in the Ab response to T cell-independent and T cell-dependent Ags. We transplanted SCID/SCID mice with human B lymphocyte subsets and immunized them with heat-inactivated Streptococcus pneumoniae or with a pneumococcal vaccine. Inactivated S. pneumoniae and soluble pneumococcal capsular polysaccharides elicited an IgM anti-polysaccharide and anti-protein Ab response from IgM memory B lymphocytes and an IgG anti-polysaccharide and anti-protein response from switched memory B lymphocytes. In addition to the IgM Ab response, IgM memory B cells elicited an IgG anti-polysaccharide and anti-protein Ab response after immunization with inactivated S. pneumoniae or soluble pneumococcal capsular polysaccharides. In conclusion, our findings provide evidence for a versatile role of IgM memory B cells in T-independent and T-dependent immune responses.
ISSN: 0022-1767
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Clinical Bacteriology and Mycology
Pediatric Pulmonology Section (-)
Laboratory of Pediatric Immunology
Experimental Laboratory Immunology
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science