Title: Human urinary protein-1 - evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions
Authors: Bernard, A ×
Roels, H
Lauwerys, R
Witters, Raphaƫl
Gielens, Constant
Soumillion, A
Van Damme, Jozef
De Ley, Marc #
Issue Date: Jan-1992
Publisher: Elsevier science bv
Series Title: Clinica chimica acta vol:207 issue:3 pages:239-49
Abstract: Protein 1 (P1), a low mol mass urinary protein of unknown function, has been purified, sequenced and quantified in human biological fluids. The molecular size, subunit composition and partial amino acid sequence of P1 are similar to those of the 10 kDa Clara cell protein (CC10), a lung secretory protein. P1 is found in high concentrations in sputum, bronchoalveolar lavages, urine and semen of healthy individuals and in urine of some pregnant women. Contrary to what is claimed, P1 or CC10 is not a specific and unique product of the lung, but like its homologue in rabbits (uteroglobulin) it is also present in urogenital secretions. P1 or CC10 may act as a natural immunosuppressor protecting the respiratory and urogenital tracts from unwanted inflammatory reactions.
ISSN: 0009-8981
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry, Molecular and Structural Biology Section
Academic Center for General Practice
Laboratory of Molecular Immunology (Rega Institute)
× corresponding author
# (joint) last author

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