Title: New routes for the synthesis of 3-and 5-substituted 2(1H)-pyrazinones
Authors: Azzam, R ×
De Borggraeve, Wim
Compernolle, Frans
Hoornaert, GJ #
Issue Date: Jan-2004
Publisher: Pergamon-elsevier science ltd
Series Title: Tetrahedron letters vol:45 issue:9 pages:1885-1888
Abstract: Various 3-(hetero)aryl, 3-alkyl and 3-alkenyl-2(1H)-pyrazinones were prepared by applying the Suzuki and Heck reaction methodology to 3,5-dichloro-2(1H)-pyrazinones. Furthermore, following hydrogenolysis of the 5-chloro substituent and regioselective 5-bromination, this palladium-catalysed cross-coupling approach could be extended to the synthesis of the analogous 5-substituted 2(1H)-pyrazinones. (C) 2004 Elsevier Ltd. All rights reserved.
ISSN: 0040-4039
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Design and Synthesis
× corresponding author
# (joint) last author

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