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Title: Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material
Authors: Mellaerts, Randy ×
Roeffaers, Maarten
Houthoofd, Kristof
Van Speybroeck, Michiel
De Cremer, Gert
Jammaer, Jasper
Van den Mooter, Guy
Augustijns, Patrick
Hofkens, Johan
Martens, Johan #
Issue Date: 2011
Publisher: Royal Society of Chemistry
Series Title: Physical Chemistry Chemical Physics vol:13 issue:7 pages:2706-2713
Abstract: The purpose of this study was to improve our understanding of the molecular organization of hydrophobic guest molecules in the presence of co-adsorbed water inside SBA-15 ordered mesoporous silica material. Understanding this adsorption competition is essential in the development of applications of controlled adsorption and desorption. The poorly water soluble drug compound itraconazole and the fluorescent probe Nile red were selected for the study. The interaction between itraconazole and SBA-15 was investigated using FT-IR, H-1 MAS NMR and Si-29 MAS NMR spectroscopy, by determination of adsorption isotherms and release kinetics in simulated gastric fluid. The distribution and migration of the hydrophobic fluorescent probe Nile red was visualized in situ using confocal fluorescence microscopy. For both molecules, there was a pronounced influence of the co-adsorbed water on adsorption, hydrophobic aggregation and migration in SBA-15 pores. These insights contribute to the development of practical methods for loading ordered mesoporous silica materials with hydrophobic molecules.
ISSN: 1463-9076
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Imaging and Photonics
Centre for Surface Chemistry and Catalysis
Drug Delivery and Disposition
× corresponding author
# (joint) last author

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